Discoveries
Explore our Discoveries
CanCOLD deepens our understanding of mild-to-moderate COPD and helps identify novel risk factors, reliable diagnostics for early detection of COPD, and helps us appropriately quantify COPD prevalence. Research using CanCOLD data advances clinical practice, guidelines and health policies for the benefit of COPD patients.
Our Key Discoveries
The table below provides an overview of publications that have made use of CanCOLD data.
Bourbeau J, et al. 2022. Ambient Air Pollution and Dysanapsis: Associations with Lung Function and COPD in the CanCOLD Study. American Journal of Respiratory and Critical Care Medicine.
Characteristics of COPD in never-smokers and ever-smokers in the general population: results from the CanCOLD study.
Undiagnosed Chronic Obstructive Pulmonary Disease Contributes to the Burden of Health Care Use
Tan, WC. et al. 2019. The effects of marijuana smoking on lung function in older people. European Respiratory Journal.
Impaired Sleep Quality in COPD Is Associated With Exacerbations: The CanCOLD Cohort Study.
Granularity of SERPINA1 alleles by DNA sequencing in CanCOLD
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Bourbeau J, et al. 2022. Ambient Air Pollution and Dysanapsis: Associations with Lung Function and COPD in the CanCOLD Study. American Journal of Respiratory and Critical Care Medicine.
Background: Long-term exposure to ambient air pollution has been linked to reduced lung function growth in children, as well as lung function decline and increased
Characteristics of COPD in never-smokers and ever-smokers in the general population: results from the CanCOLD study.
Tan, W.C., et al., Thorax, 2015. 70(9): p. 822-829. Key findings: COPD in never-smokers forms a substantial burden in the population: nearly 30% of CanCOLD subjects with COPD had never smoked . COPD in never-smokers was more likely to affect women compared with men.
Undiagnosed Chronic Obstructive Pulmonary Disease Contributes to the Burden of Health Care Use
Background: Alpha-1 antitrypsin (AAT) deficiency (AATD) is an inherited condition characterized by low AAT serum concentrations and is associated with an accelerated rate of lung function decline, early onset emphysema and an increased risk of Chronic Obstructive Pulmonary Disease (COPD). AATD is caused by genetic mutations in the SERPINA1 gene. DNA sequencing provides a complete assessment of the mutated gene by detecting its conventional mutated alleles and its rare and novel genetic variants. Little is known about how common these deficient alleles are in the Canadian population and their individual and cumulative impacts on COPD phenotypes including lung function decline and emphysema.
Tan, WC. et al. 2019. The effects of marijuana smoking on lung function in older people. European Respiratory Journal.
Background: Marijuana is the second most common substance smoked worldwide after tobacco. Previous studies have associated marijuana exposure with increased respiratory symptoms and chronic bronchitis among long-term cannabis smokers. However, the long-term effects of marijuana smoking on lung function remain unclear.
Impaired Sleep Quality in COPD Is Associated With Exacerbations: The CanCOLD Cohort Study.
Shorofsky, M., et al., Chest, 2019. Key findings: Poor sleep quality in individuals with COPD is associated with risk of symptom-based (dyspnea or sputum change ≥ 48 h) and event-based (symptoms plus medication or unscheduled health services use) COPD exacerbations. Typography
Granularity of SERPINA1 alleles by DNA sequencing in CanCOLD
Gupta, Nisha, et al. European Respiratory Journal, 2020. Key findings: Poor sleep quality in individuals with COPD is associated with risk of symptom-based (dyspnea or sputum change ≥ 48 h) and event-based (symptoms plus medication or unscheduled health services use) COPD exacerbations. Background: Alpha-1 antitrypsin (AAT) deficiency (AATD) is an inherited condition characterized by low … Read more
Publications
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Year | Author | Title | Journal/Publisher | Link | Type |
2021 | Vameghestahbanati, M. et al. | Dysanapsis and the Spirometric Response to Inhaled Bronchodilator | Am J Respir Crit Care Med | Journal Article | |
2021 | Krishnan, S. | Chronic obstructive pulmonary disease categorization using … | McGill University | Journal Article | |
2021 | Tan, WC. et al. | High eosinophil counts predict decline in FEV1: results from the CanCOLD… | Eur Respir J | Journal Article | |
2021 | Cherian, M. et al. | Dyspnoea and symptom burden in mild-moderate COPD: the Canadian Cohort… | ERJ Open Res | Journal Article | |
2021 | Leung, C. et al. | The Prevalence of Chronic Obstructive Pulmonary Disease (COPD) and the … | Int J Chron Obstruct Pulmon Dis | Journal Article | |
2021 | Lewthwaite, H. et al. | Normative Cardiopulmonary Exercise Test Responses at the Ventilatory Threshold… | Chest | Journal Article | |
2020 | Oostrik, L. | Physical activity and its associated factors in Canadian individuals with … | Utrecht University | Journal Article | |
2020 | Johnson, K. | Evaluating strategies for the early detection of chronic obstructive pulmonary … | University of British Columbia | Journal Article | |
2020 | Barrecheguren, M. et al. | Identification and definition of asthma-COPD overlap: The CanCOLD study | Respirology | Journal Article |
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